Publications du LI2P

1. Principales publications du  Li2P

Saidenberg-Kermanac'h N, Semerano L, Naccache JM, Brauner M, Falgarone G, Dumont-Fischer D, Guillot X, Valeyre D, Boissier MC. Screening for latent tuberculosis in anti-TNF-α candidate patients in a high tuberculosis incidence setting. Int J Tuberc Lung Dis. 2012 Oct;16(10):1307-14.

Biton J, Boissier MC, Bessis N. TNFα: activator or inhibitor of regulatory T cells? Joint Bone Spine. 2012 Mar;79(2):119-23.

Boissier MC, Semerano L, Challal S, Saidenberg-Kermanac'h N, Falgarone G. Rheumatoid arthritis: from autoimmunity to synovitis and joint destruction. J Autoimmun. 2012 Sep;39(3):222-8.

Singh-Jasuja H*, Thiolat A*, Ribon M, Boissier MC, Bessis N, Rammensee HG, Decker P. The mouse dendritic cell marker CD11c is down-regulated upon cell activation through Toll-like receptor triggering. Immunobiology. 2013 Jan;218(1):28-39.* equal contribution

Assier E, Semerano L, Duvallet E, Delavallée L, Bernier E, Laborie M, Grouard-Vogel G, Larcier P, Bessis N, Boissier MC. Modulation of anti-tumor necrosis factor alpha (TNF-α) antibody secretion in mice immunized with TNF-α kinoid. Clin Vaccine Immunol. 2012 May;19(5):699-703.

Semerano L, Assier E, Boissier MC. Anti-cytokine vaccination: a new biotherapy of autoimmunity? Autoimmun Rev. 2012 Sep;11(11):785.

Rullé S, Ah Kioon MD, Asensio C, Mussard J, Ea HK, Boissier MC, Lioté F, Falgarone G. Adrenomedullin, a neuropeptide with immunoregulatory properties induces semi-mature tolerogenic dendritic cells. Immunology. 2012 Jun;136(2):252-64.

Ratsimandresy RA, Duvallet E, Assier E, Semerano L, Delavallée L, Bessis N, Zagury JF, Boissier MC Active immunization against IL-23p19 improves experimental arthritis. Vaccine. 2011 Nov 21;29(50):9329-36

Biton J, Semerano L, Delavallée L, Lemeiter D, Laborie M, Grouard-Vogel G, Boissier MC, Bessis N. Interplay between TNF and regulatory T cells in a TNF-driven murine model of arthritis. J Immunol. 2011 Apr 1;186:3899-910.

Semerano L, Assier E, Delavallée L, Boissier MC. Kinoid of human tumor necrosis factor-alpha for rheumatoid arthritis. Expert Opin Biol Ther. 2011 Apr;11(4):545-50. Mar 9.

Decker P. Neutrophils and interferon-a-producing cells: who produces interferon in lupus? Arthritis Res Ther, 2011, 13:118-20.

Veenbergen S, Bennink MB, Affandi AJ, Bessis N, Biton J, Arntz OJ, van den Berg WB, van de Loo FA. A pivotal role for antigen-presenting cells overexpressing SOCS3 in controlling invariant NKT cell responses during collagen-induced arthritis.  Ann Rheum Dis. 2011 Dec;70(12):2167-75.

Duvallet E, Semerano L, Assier E, Falgarone G, Boissier MC. Interleukin-23: A key cytokine in inflammatory diseases. Ann Med. Ann Med. 2011 Nov;43(7):503-11.

Boissier MC. Cell and cytokine imbalances in rheumatoid synovitis. Joint Bone Spine. 2011 ;78:230-4.

Assier E, Boissier MC, Dayer JM. Interleukin-6: from identification of the cytokine to development of targeted treatments. Joint Bone Spine. 2010 ;77:532-6.

Semerano L, Clavel G, Assier E, Denys A, Boissier MC. Blood vessels, a potential therapeutic target in rheumatoid arthritis? Joint Bone Spine. 2011;78:118-23.

Denys A, Thiolat A, Descamps D, Lemeiter D, Benihoud K, Bessis N, Boissier MC.Intra-articular electrotransfer of mouse soluble tumour necrosis factor receptor in a murine model of rheumatoid arthritis. J Gene Med. 2010;12:659-68.

Miellot-Gafsou A, Biton J, Bourgeois E, Herbelin A, Boissier MC, Bessis N. Early activation of invariant natural killer T cells in a rheumatoid arthritis model and application to disease treatment. Immunology. 2010 ;130:296-306.

Delavallée L, Semerano L, Assier E, Vogel G, Vuagniaux G, Laborie M, Zagury D, Bessis N, Boissier MC. Active immunization to tumor necrosis factor-alpha is effective in treating chronic established inflammatory disease: a long-term study in a transgenic model of arthritis. Arthritis Res Ther. 2009;11(6):R195. Epub 2009 Dec 23.

Boissier MC, Assier E, Biton J, Denys A, Falgarone G, Bessis N. Regulatory T cells (Treg) in rheumatoid arthritis. Joint Bone Spine. 2009;76:10-4.

Jaen O, Petit-Teixeira E, Kirsten H, Ahnert P, Semerano L, Pierlot C, Cornelis F, Boissier MC, Falgarone G; European Consortium on Rheumatoid Arthritis Families.No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis. Arthritis Res Ther. 2009;11:R5. Epub 2009 Jan 13.

Jaen O, Rullé S, Bessis N, Zago A, Boissier MC, Falgarone G. Dendritic cells modulated by innate immunity improve collagen-induced arthritis and induce regulatory T cells in vivo. Immunology. 2009;126:35-44..

Launois R, Payet S, Saidenberg-Kermanac'h N, Francesconi C, França LR, Boissier MC. Budget impact model of rituximab after failure of one or more TNFalpha inhibitor therapies in the treatment of rheumatoid arthritis.Joint Bone Spine. 2008;75:688-95.

Boissier MC, Assier E, Falgarone G, Bessis N Shifting the imbalance from Th1/Th2 to Th17/treg: the changing rheumatoid arthritis paradigm. Joint Bone Spine. 2008;75:373-5.
Clavel G, Marchiol-Fournigault C, Renault G, Boissier MC, Fradelizi D, Bessis

N. Ultrasound and Doppler micro-imaging in a model of rheumatoid arthritis in mice. Ann Rheum Dis. 2008 ;67:1765-72.
Delavallée L, Assier E, Semerano L, Bessis N, Boissier MC. Emerging applications of anticytokine vaccines. Expert Rev Vaccines. 2008;7:1507-17..

Delavallée L, Assier E, Denys A, Falgarone G, Zagury JF, Muller S, Bessis N, Boissier MC Vaccination with cytokines in autoimmune diseases. Ann Med. 2008;40:343-51.

Delavallée L, Le Buanec H, Bessis N, Assier E, Denys A, Bizzini B, Zagury D, Boissier MC. Early and long-lasting protection from arthritis in tumour necrosis factor alpha (TNFalpha) transgenic mice vaccinated against TNFalpha. Ann Rheum Dis. 2008;67:1332-8.

Boissier M-C, Lemeiter D., Valvason C Clavel G, Laroche L. , Begue T., and Bessis N. Synoviocytes infection by AAV is neutralized by human synovial fluid from arthritis patients and depends on AAV serotype. Hum Gene Ther, 2007 , 18 : 525-35.

Clavel C, Bessis N, Fardellone P, Othmane M, Menard JF, Pouplin S, Boumier P, Vittecoq O, Le Loêt X, Boissier MC. Angiogenesis markers (VEGF, soluble receptor of VEGF and angiopoietin-1) in very early arthritis and their association with inflammation and joint destruction. Clin Immunol,2007, 124: 158-64.

Le Buanec H*, Delavallée L*, Bessis N,  Paturance S, Bizzini B, Gallo R,  Zagury D, Boissier MC. TNFα kinoid vaccination-induced neutralizing antibodies to TNFα protects mice from autologous TNFα driven chronic and acute inflammation (* same ctd). Proc Natl Acad Sci, 2006,103:19442-7

Bertin-Maghit SM, Capini CJ , Bessis N, Chomilier J, Muller S, Abbas A, Regulier EG, Rappaport J, Therwath A, Zagury JF*, Boissier MC*. Improvement of collagen-induced arthritis by active immunization against murine IL-1 peptides designed by molecular modelling. Vaccine 2005, 23:4228-35 (* same cont.)

Maravic M, Bergé C, Daurès JP, Boissier MC Practices for Managing a Flare of Long-Standing Rheumatoid Arthritis: Survey among French Rheumatologists, Clin Exp Immunol, 2005,23:36-42

Saidenberg-Kermanac’h N, Corrado A, Lemeiter D, de Vernejoul MC, Boissier MC, Cohen-Solal M. TNF-a antibodies and osteoprotegerin decrease systemic bonne loss-associated with inflammation through distinct mechanisms in collagen-induced arthritis. Bone, 2004, 35:1200-7

Bessis N*, Bloquel N*, Boissier MC, Scherman D, Bigey P. Gene therapy of collagen-induced arthritis by electrotransfer of human tumor necrosis factor-alpha soluble receptor I variants. Hum Gene Ther 2004 ; 15 : 189-201

Cottard V, Valvasson C, Falgarone G, Lutomski D, Boissier MC, Bessis N Effect of Synovial Fluid on Adeno-Associated Virus-Mediated Gene Transfer to Chondrocytes J Clin Immunol, 2004, 24 : 162-9

Garcia de la Pena-Lefebvre P, Chanseaud Y, Tamby MC, Reinbolt J, Batteux F, Allanore Y, Kahan A, Meyer O, Benveniste O, Boyer O, Guillevin L, Boissier MC, Mouthon L. IgG reactivity with a 100 kDa tissue and endothelial cell antigen identified as topoisomerase 1 distinguishes between limited abd diffuse systemic sclerosis patients. Clin Immunol 2004, 11:241-51

Maravic M, Bergé C, Daurès JP, Boissier MC Survey of Practices Regarding Management of Early Typical Rheumatoid Arthritis by Rheumatologists in France, Clin Exp Rheumatol, 2004, 22:319-27

Saidenberg-Kermanac’h N, Bessis N, Lemeiter D, de Vernejoul MC, Boissier MC, Cohen-Solal M. Osteoprotegerin and interleukin-4 cellular gene therapy decrease bone resorption-associated inflammation in collagen-induced arthritis. J Clin Immunol, 2004, 24 :370-8

Saidenberg-Kermanac’h N, Bessis N, Deleuze V, Blocquel C, Bureau M, Scherman D,Boissier MC. Efficacy of interleukin-10 gene electrotransfer into skelettal muscle in mice with collagen-induced arthritis, J Gene Med, 2003, 5; 164-71

Bessis N, Cottard V, Saidenberg-Kermanac’h N, Lemeiter D, Fournier C, Boissier MC. Syngeneic fibroblasts engineered to secrete interleukin-4 as vectors for antiinflammatory gene therapy in collagen-induced arthritis. J Gene Med, 2002, 4 :300-7

Saidenberg-Kermanac’h N, Bessis N, Cohen-Solal M, de Vernejoul M, Boissier MC. Osteoprotegerin and inflammation. Eur Cytokine Netw, 2002, 13 :144-53

Bessis N, Doucet C, Cottard V, Douar AM, Firat H, Jorgensen C, Mezzina M, Boissier MC Gene therapy for rheumatoid arthritis, J Gene Med, 2002 ;4 :581-91

Guedes C, Bianchi-Fior P, Cormier B, Barthelemy B, Rat AC, Boissier MC. Cardiac manifestations of rheumatoid arthritis : a case control transoesophageal echocardiography study in 30 patients. Arthritis Rheum , 2001, 45:129-35.

Guéry L, Chiocchia G, Batteux F, Boissier MC C, Fournier C. Collagen II-pulsed antigen-presenting cells engineered to secrete IL-4 down regulate collagen-induced arthritis. Gene Ther, 2001, 8 : 1855,62

Guéry L, BatteuxF, Bessis N, Bréban M, Boissier MC, Fournier C, Chiocchia G. Expression of fas ligand improves the therapeutic effect if IL-4 in collagen-induced arthritis. Eur J Immunol, 2000;30:308-15

Bessis N, Guéry L, Mantovani A, Vecchi A, Sims J, Fradelizi D, Boissier MC. The type II decoy receptor of IL-1 inhibits murine collagen-induced arthritis, Eur J Immunol,2000;30:867-75

Cottard V, Mulleman Bouillé P, Mezzina M, Boissier MC, Bessis N. Adeno-associated virus mediated delivery of IL-4 prevents collagen-induced arthritis. Gene Ther, 2000; 7: 1930-9

2. Publications antérieures hors Li2P de membres actuels du Li2P

Lindau D, Rönnefarth V, Erbacher A, Rammensee HG, Decker P. Nucleosome-induced neutrophil activation occurs independently of TLR9 and endosomal acidification: implications for systemic lupus erythematosus. Eur J Immunol, 2011, 41:669-81.


Bürk K, Wick M, Roth G, Decker P, Voltz, R. Antineuronal antibodies in sporadic late-onset cerebellar ataxia. J Neurol, 2010, 257:59-62.

Bürk K, Farecki ML, Lamprecht G, Roth G, Decker P, Weller M, Rammensee HG, Oertel WHO. Neurological symptoms in patients with biopsy proven celiac disease. Mov Disord, 2009, 24:2358-62.

Lindau D, Decker P. Neutrophils, dendritic cells and chromatin-mediated pathogenesis in systemic lupus erythematosus. Autoimmunity, 2009, 42:254-6.

Erbacher A, Decker P. Chromatin modifications, oxidative stress and nucleosome autoantibodies. In: The epigenetics of autoimmune diseases, 2009, 119-34. Editor, Moncef Zouali; Publisher, Wiley Inc., New York.

Kloss M*, Decker P*, Baltz K, Baessler T, Jung G, Rammensee HG, Steinle A, Krusch M, Salih H. Interaction of monocytes with NK cells upon Toll-like receptor-induced expression of the NKG2D ligand MICA. J Immunol, 2008, 181: 6711-19. *The first two authors contributed equally to this work.

Hervé R, Schmitz T, Evain-Brion D, Cabrol D, Leroy MJ, Méhats C. The PDE4 inhibitor rolipram prevents NF-kappaB binding activity and proinflammatory cytokine release in human chorionic cells. J Immunol. 2008 Aug 1;181(3):2196-202.

Erbacher A, Rönnefarth V, Decker P. Circulating nucleosomes due to a defective clearance of dying cells: consequences in systemic lupus erythematosus. Autoimmunity, 2007, 40:311-14.

Dali H, Busnel O, Hoebeke J, Bi L, Decker P, Briand JP, Baudy-Floc’h M, Muller S. Heteroclitic properties of mixed a- and aza-b3-peptides mimicking a supradominant CD4 T cell epitope presented by nucleosome. Mol Immunol, 2007, 44:3024-36.

Rönnefarth V, Erbacher A, Lamkemeyer T, Madlung J, Nordheim A, Rammensee HG, Decker P. TLR2/TLR4-independent neutrophil activation and recruitment upon endocytosis of nucleosomes reveals a new pathway of innate immunity in systemic lupus erythematosus. J Immunol, 2006, 177:7740-9.

Decker P, Kötter I, Klein R, Berner B, Rammensee HG. Monocyte-derived dendritic cells over-express CD86 in patients with systemic lupus erythematosus. Rheumatology, 2006, 45:1087-95.

Decker P, Singh-Jasuja H, Haager S, Kötter I, Rammensee HG. Nucleosome, the main autoantigen in systemic lupus erythematosus, induces direct dendritic cell activation via a MyD88-independent pathway: consequences on inflammation. J Immunol, 2005, 174:3326-34.

Dengjel J*, Decker P*, Schoor O, Altenberend F, Weinschenk T, Rammensee HG, Stevanovic S. Identification of a naturally processed cyclin D1 T-helper epitope by a novel combination of HLA class II targeting and differential mass spectromotry. Eur J Immunol, 2004, 34:3644-51. *The first two authors contributed equally to this work.

Decker P, Wolburg H, Rammensee HG. Nucleosomes induce lymphocyte necrosis. Eur J Immunol, 2003, 33:1978-87.

Williams RC, Malone CC, Meyers C, Decker P, Muller S. Detection of nucleosome particles in the sera of patients with SLE using monoclonal antibody 4H7. J Rheumatol, 2001, 28:81-94.

Decker P, Isenberg DA, Muller S. Inhibition of caspase-3-mediated poly(ADP-ribose) polymerase apoptotic cleavage by human PARP autoantibodies and effect on cells undergoing apoptosis. J Biol Chem, 2000, 275:9043-6.

Monestier M, Decker P, Briand JP, Gabriel JL, Muller S. Molecular and structural properties of three autoimmune IgG monoclonal antibodies to histone H2B. J Biol Chem, 2000, 275:13558-63.

Decker P, Le Moal A, Briand JP, Muller S. Identification of a minimal T cell epitope recognised by anti-nucleosome Th cells in the C-terminal region of histone H4. J Immunol, 2000, 165:654-62.